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KMID : 0370220220660020090
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Yakhak Hoeji
2022 Volume.66 No. 2 p.90 ~ p.96
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Concurrent Use of Prescribed OTC · ETC Drugs and Herbal Medicines in South Korea: Exploring Potential Herb-drug Interactions
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Park Sang-Jun
Oh In-Sun
Park Min-Jung
Jang Bo-Hyoung
Shin Ju-Young
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Abstract
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Herbal medicines have gained a reputation for being efficacious and safe over hundreds of years. Nowadays,people are easily exposed to drugs and herbal medications concurrently. Therefore, it is essential for regulatory authoritiesand physicians to closely monitor potential herb-drug interactions. The aim of this study was to determine (1) theprevalence of the concurrent use of drugs and herbal medications, (2) demographic and clinical characteristics ofconcurrent users, (3) risk factors associated with concurrent use, (4) prescription patterns, and (5) potential herb-druginteractions by using a nationwide insurance claims database. We included patients with herbal medicine records in 2010-2015 from the National Health Insurance Service-National Sample Cohort 2.0. The herbal medicine users were divided intotwo groups: concurrent users who were prescribed both herbal and drug medications simultaneously and non-concurrentusers. The proportion of concurrent use increased steadily from 2.5% in 2010 to 5.2% in 2015, and the growth rate inthe elderly population aged 60-79 years was the highest, from 0.7% in 2010 to 2.8% in 2015. Concurrent users in 2015were prone to be female; old; and have chronic diseases including hypertension (adjusted odds ratio [aOR], 4.89; 95% CI,4.54-5.27), hyperlipidemia (aOR, 2.01; 1.89-2.14), and diabetes (aOR, 1.81; 1.67-1.98). The most common concurrentlyused combinations were Gunghatang-aspirin, Ojeoksan-aspirin, and Ojeoksan-atorvastatin. In this study, we investigated theherb-drug combinations that are used concurrently and related characteristics and elucidated the factors related to theconcurrent use and the most common concurrently used herb-drug combinations.
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KEYWORD
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Drug, Herbal medicine, Concurrent use, Herb-drug interaction
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